In 2020, the World Health Organization launched a major initiative to eliminate cervical cancer globally. The initiative is built around the three key pillars of human papillomavirus (HPV) vaccination, cervical screening and treatment, with associated intervention targets for the year 2030. The ‘90-70-90’ targets specify that 90% of adolescent girls receive prophylactic HPV vaccination, 70% of adult women receive a minimum twice-in-a-lifetime cervical HPV test and 90% receive appropriate treatment for preinvasive or invasive disease. Modelling has shown that if these targets are met, the elimination of cervical cancer, defined as fewer than four cases per 100 000 women per annum, will be achieved within a century. Many high-income countries are well positioned to eliminate cervical cancer within the coming decades, but few have achieved ‘90-70-90’ and many challenges must still be addressed to deliver these critical interventions effectively. This review considers the current status of cervical cancer control in relation to each of the three elimination pillars in high-income countries and discusses some of the developments that will assist countries in reaching these ambitious targets by 2030.

2020年，世界卫生组织发起了全球消除宫颈癌的重大倡议。该倡议围绕人乳头瘤病毒 (HPV) 疫苗接种、宫颈筛查和治疗三大关键支柱，以及 2030 年的相关干预目标。“90-70-90”目标明确规定 90% 的青春期女孩接受预防性 HPV 接种通过疫苗接种，70% 的成年女性一生中至少接受两次宫颈 HPV 检测，90% 的女性接受针对侵袭前或侵袭性疾病的适当治疗。模型显示，如果实现这些目标，将在一个世纪内实现消除宫颈癌（定义为每年每 10 万名女性中少于 4 例）。许多高收入国家完全有能力在未来几十年内消除宫颈癌，但很少有国家能够实现“90-70-90”，并且仍然必须解决许多挑战才能有效地提供这些关键干预措施。本次审查考虑了高收入国家宫颈癌控制与三大消除支柱相关的现状，并讨论了一些有助于各国在 2030 年实现这些雄心勃勃的目标的进展。