Inhibition of the competence regulon in Streptococcus pneumoniae, either by signal-based peptide inhibitors “dnCSPs” or through small moleculebased “COM blockers”, attenuates pneumococcus virulence. Muralikrishna Lella and Yftah Tal-Gan review the latest progress on these compounds and how they can be applied to treat pneumococcal infections. (doi: 10.1002/pep2.24222)

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通过基于信号的肽抑制剂“dnCSPs”或通过基于小分子的“COM阻断剂”抑制肺炎链球菌的能力调节子，减弱肺炎球菌的毒力。Muralikrishna Lella 和 Yftah Tal-Gan 回顾了这些化合物的最新进展以及它们如何用于治疗肺炎球菌感染。(doi: 10.1002/pep2.24222)