Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile,Neuropathology and Applied Neurobiology

当前位置： X-MOL 学术 › Neuropathol. Appl. Neurobiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-07-23 , DOI: 10.1111/nan.12754
Richard A Hickman ₁ , John T Gionco ₁ , Phyllis L Faust ₁ , Michael L Miller ₁ , Jeffrey Bruce ₂ , Gabrielle Page-Wilson ₃ , Marc K Rosenblum ₄ , Sylvia L Asa ₅

Affiliation

We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.

中文翻译：

具有肾上腺皮质细胞的垂体促肾上腺皮质激素肿瘤：具有独特形态和甲基化谱的独特临床病理实体

我们描述了一种罕见的 TPIT 阳性促肾上腺皮质激素 PitNET，它与 SF1 阳性肾上腺皮质细胞混合。通过免疫荧光检测，这种二形性细胞群显示 TPIT 和 SF1 之间没有共定位，并且肾上腺皮质分支瘤受到青睐。甲基化阵列分析揭示了与其他垂体肿瘤相关的新型甲基化谱。

更新日期：2021-07-23

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11