Cinnamon essential oil-mesoporous silica nanoparticles (CEO-MSNPs)/potato starch films have better antifungal activity against molds commonly found in post-harvest white mushrooms. The antifungal effects of CEO-MSNPs against Mucor sp. FJ09 species and Mucor circinelloides CNRMA 03.0371 were investigated. The antifungal mechanisms of CEO-MSNPs against molds were elucidated. Results showed that after adding CEO-MSNPs at the minimum inhibitory concentration level, there were obvious changes in membrane permeability, reactive oxygen species (ROS) content, cell component leakage, cell component leakage, soluble sugar, and malondialdehyde (MDA) content. The scanning electron microscope assay showed that CEO-MSNPs effectively destroyed the mycelial morphology of Mucor sp. FJ09 species and Mucor circinelloides CNRMA 03.0371, and interfered with their normal growth. Notably, CEO-MSNPs could be in the up-regulation of nox1 and nox2 genes of Mucor sp. FJ09 species and Mucor circinelloides CNRMA 03.0371 to generate a large number of reactive oxygen species, thereby inhibiting spore germination and growth. The results of this study could provide a reference for screening key targets of drug resistance of molds in post-harvest white mushrooms.

肉桂精油-介孔二氧化硅纳米粒子（CEO-MSNPs）/马铃薯淀粉薄膜对收获后白蘑菇中常见的霉菌具有更好的抗真菌活性。CEO-MSNPs 对毛霉菌的抗真菌作用。研究了 FJ09 物种和圆环毛霉CNRMA 03.0371。阐明了 CEO-MSNPs 对霉菌的抗真菌机制。结果表明，在最低抑菌浓度水平添加CEO-MSNPs后，膜通透性、活性氧(ROS)含量、细胞成分渗漏、细胞成分渗漏、可溶性糖、丙二醛(MDA)含量均有明显变化。扫描电镜分析表明，CEO-MSNPs有效破坏了毛霉病菌的菌丝形态sp. FJ09 种和毛霉菌CNRMA 03.0371，并干扰了它​​们的正常生长。值得注意的是，CEO-MSNPs 可能上调毛霉菌属的 nox1 和 nox2 基因。FJ09种与圆环毛霉CNRMA 03.0371产生大量活性氧，从而抑制孢子萌发和生长。本研究结果可为采后白蘑菇霉菌抗药性关键靶点的筛选提供参考。