Breweries generate a high amount of brewer’s spent grains (BSG), which is a valuable feedstock for industrial applications. In the current study, a techno-economic assessment of the flow-through subcritical water hydrolysis reactor to produce sugars from BSG was performed. Simulations were done for a sequential hydrolysis process in three-extractor vessels of 10 L (pilot-plant) and 500 L (industrial-plant), coupled or not to a separation system. The sugar separation system was composed of a five-zone simulated moving bed (SMB) process. A study on the cost of manufacturing (COM), profitability indicators, and sensitivity analysis was conducted to verify the project feasibility. Moreover, the mass and energy balance of the industrial process was accomplished to evidence the main operational parameters. Simulation results indicated that the scale-up process from pilot to industrial scale reduced the COM by approximately 80 %. In the process coupled with the SMB separation system, arabinose and galactose represented 83.68 % of the costs for sugars separation. Arabinose COM decreased from 64.10 USD kg^–1 in pilot-plant to 7.22 USD kg^–1 in industrial-plant. The implementation of a separation system recovering six sugars with high added-value can be an advantage in the industrial-plant process when comparing to the process without SMB process, which produces a single hydrolysate fraction with low commercial value. Finally, the integrated subcritical water hydrolysis of BSG coupled with a separation system can be a promising alternative to produce different concentrated sugars in a biorefinery concept.

啤酒厂产生大量啤酒糟 (BSG)，这是工业应用的宝贵原料。在当前的研究中，对流通式亚临界水水解反应器从 BSG 生产糖进行了技术经济评估。在 10 升（中试工厂）和 500 升（工业工厂）的三个提取器容器中对连续水解过程进行了模拟，这些容器连接或不连接到分离系统。糖分离系统由五区模拟移动床 (SMB) 工艺组成。对制造成本 (COM)、盈利指标和敏感性分析进行了研究，以验证项目的可行性。此外，完成了工业过程的质量和能量平衡以证明主要操作参数。模拟结果表明，从中试规模到工业规模的放大过程使 COM 降低了大约 80%。在与 SMB 分离系统结合的过程中，阿拉伯糖和半乳糖占糖分离成本的 83.68%。阿拉伯糖 COM 从 64.10 USD kg 下降^–1在中试工厂到 7.22 USD kg ^–1在工业工厂。与没有 SMB 工艺的工艺相比，回收六种具有高附加值的糖的分离系统的实施在工业设备工艺中可能是一个优势，因为没有 SMB 工艺，它产生一个具有低商业价值的单一水解产物馏分。最后，BSG 的集成亚临界水水解与分离系统相结合，可以成为在生物精炼概念中生产不同浓缩糖的有前途的替代方案。