Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines,Molecular Diversity

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Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines
Molecular Diversity ( IF 3.9 ) Pub Date : 2021-07-22 , DOI: 10.1007/s11030-021-10275-7
Merla Arjuna Rajendra ₁ , Muhammad Naseem ₂ , Muthipeedika Nibin Joy ₃ , K Sunil ₁ , Ayyiliath Meleveetil Sajith ₄ , Fares Howari ₂ , Yousef Nazzal ₂ , Cijo Xavier ₂ , Mohammed B Alshammari ₅ , Karickal Raman Haridas ₄

Affiliation

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage.