We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM⁺ cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity.

我们研究了JNK和p53参与实现小鼠脑室下区不同类型祖细胞的生长潜力和神经胶质细胞分泌神经营养因子。显示了这些信号分子在多能神经干细胞的有丝分裂活动和特化中的刺激作用。发现 JNK 和 p53 不参与定向神经元祖细胞（克隆形成 PSA-NCAM ⁺细胞）。揭示了个体神经胶质细胞群中的神经营养生长因子对这些蛋白激酶和转录因子的活性的依赖性。JNK 和 p53 在星形胶质细胞中的作用在于刺激它们的分泌，而在小胶质细胞中则相反，在于其抑制作用。少突胶质细胞的分泌性神经营养功能与 JNK 和 p53 活性无关。