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Peculiarities of the Composition of Peripheral Immune Cells and Cytokine Profile in Brain Structures in Mutant DISC1-L100P Mice
Bulletin of Experimental Biology and Medicine ( IF 0.9 ) Pub Date : 2021-07-23 , DOI: 10.1007/s10517-021-05225-0
E L Al'perina 1 , M M Gevorgyan 1 , S Ya Zhanaeva 1 , T V Lipina 1 , G V Idova 1
Affiliation  

Intact Disc1-L100P mice carrying a point mutation DISC1Rgsc1390 in the second exon of the DISC1 gene (genetic model of schizophrenia) differ from the parental C57BL/6NCrl strain by higher content of CD3+ T cells and reduced number of CD19+B cells in the peripheral blood and spleen. Analysis of T cell subpopulations revealed an increase in the number of CD3+CD4+ T helpers in the blood of mutant mice and a decrease in the level of CD3+CD8+ suppressor/cytotoxic T cells and CD3+CD4+CD25+ T-regulatory cells. The distribution pattern of inflammatory (IL-1β, IL-2, IL-6, IL-17, IFNγ, and TNFα) and anti-inflammatory (IL-4, IL-10) cytokines specific for Disc1-L100P mice was revealed in the brain structures involved in the pathogenesis of schizophrenia. A possible implication of immune mechanisms in the development of schizophrenia-like endophenotype of Disc1-L100P mice is discussed.



中文翻译:

突变 DISC1-L100P 小鼠脑结构中外周免疫细胞组成和细胞因子谱的特点

DISC1基因的第二个外显子(精神分裂症的遗传模型)中携带点突变 DISC1 Rgsc1390 的完整 Disc1-L100P 小鼠与亲本 C57BL/6NCrl 品系的不同之处在于 CD3 + T 细胞含量更高,CD19 + B 细胞数量减少外周血和脾脏。T 细胞亚群分析显示突变小鼠血液中 CD3 + CD4 + T 辅助细胞的数量增加,CD3 + CD8 +抑制/细胞毒性 T 细胞和 CD3 + CD4 + CD25 + 水平降低T调节细胞。Disc1-L100P 小鼠特异性的炎症(IL-1β、IL-2、IL-6、IL-17、IFNγ 和 TNFα)和抗炎(IL-4、IL-10)细胞因子的分布模式在与精神分裂症发病机制有关的大脑结构。讨论了免疫机制在 Disc1-L100P 小鼠精神分裂症样内表型发展中的可能影响。

更新日期:2021-07-23
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