Anorexia nervosa (AN) is a complex psychiatric disorder with poorly understood etiology. Numerous voxel-based morphometry (VBM) and resting-state functional imaging studies have provided strong evidence of abnormal brain structure and intrinsic and functional activities in AN, but with inconsistent conclusions. Herein, a whole-brain meta-analysis was conducted on VBM (660 patients with AN, and 740 controls) and resting-state functional imaging (425 patients with AN, and 461 controls) studies that measured differences in the gray matter volume (GMV) and intrinsic functional activity between patients with AN and healthy controls (HCs). Overall, patients with AN displayed decreased GMV in the bilateral median cingulate cortex (extending to the bilateral anterior and posterior cingulate cortex), and left middle occipital gyrus (extending to the left inferior parietal lobe). In resting-state functional imaging studies, patients with AN displayed decreased resting-state functional activity in the bilateral anterior cingulate cortex and bilateral median cingulate cortex, and increased resting-state functional activity in the right parahippocampal gyrus. This multimodal meta-analysis identified reductions of gray matter and functional activity in the anterior and median cingulate in patients with AN, which contributes to further understanding of the pathophysiology of AN.

中文翻译：

---

神经性厌食症的结构和功能性脑改变：神经影像学研究的多模式荟萃分析

神经性厌食症（AN）是一种复杂的精神疾病，其病因知之甚少。大量基于体素的形态测量 (VBM) 和静息状态功能成像研究提供了 AN 异常大脑结构和内在和功能活动的有力证据，但结论不一致。在此，对 VBM（660 名 AN 患者和 740 名对照）和静息状态功能成像（425 名 AN 患者和 461 名对照）研究进行了全脑荟萃分析，这些研究测量了灰质体积（GMV）的差异) 和 AN 患者与健康对照 (HC) 之间的内在功能活动。总体而言，AN 患者的双侧正中扣带皮层（延伸至双侧前部和后部扣带皮层）的 GMV 降低，左侧枕中回（延伸至左侧顶下叶）。在静息状态功能成像研究中，AN 患者的双侧前扣带皮层和双侧正中扣带皮层的静息状态功能活动降低，而右侧海马旁回的静息状态功能活动增加。这项多模式荟萃分析确定了 AN 患者前部和中部扣带回的灰质和功能活动减少，这有助于进一步了解 AN 的病理生理学。并增加右侧海马旁回的静息状态功能活动。这项多模式荟萃分析确定了 AN 患者前部和中部扣带回的灰质和功能活动减少，这有助于进一步了解 AN 的病理生理学。并增加右侧海马旁回的静息状态功能活动。这项多模式荟萃分析确定了 AN 患者前部和中部扣带回的灰质和功能活动减少，这有助于进一步了解 AN 的病理生理学。