当前位置: X-MOL 学术Bioorg. Med. Chem. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cytotoxic oxidovanadium(IV) complexes of tridentate halogen‐substituted Schiff bases: First dinuclear V(IV) complexes with O → VIV = O → VIV = O core
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2021-07-23 , DOI: 10.1016/j.bmcl.2021.128285
Hadi Amiri Rudbari 1 , Arezoo Saadati 1 , Mahnaz Aryaeifar 1 , Isabel Correia 2 , Fernanda Marques 3 , Olivier Blacque 4 , Nicola Micale 5
Affiliation  

The reaction of potentially N,N,O-tridentate Schiff base ligands, Cl-LH, Br-LH, BrCl-LH and H-LH, with [VIVO(acac)2] in 2:1 ratio in methanol gave the corresponding mononuclear and dinuclear oxidovanadium(IV) complexes, VO(Cl-L)2 (1), VO(Br-L)2 (2), [(BrCl-L)2(H2O)V(μ-O)VO(BrCl-L)2] (3) and [(H-L)2(H2O)V(μ -O)VO(H-L)2] (4), in good yields. The ligands and complexes were fully characterized by elemental analysis and FT-IR spectroscopy. The ligands were also characterized by 1H NMR spectroscopy. The oxidation state of V(IV)O with d1 configuration in all synthesized complexes was confirmed by EPR. Moreover, the structures of 2 and 3 were determined by X-ray diffraction (XRD) analysis which revealed them as mono- and dinuclear vanadium(IV) complexes, respectively, with the ligands coordinated as bidentate chelates. The structure of 3 represents the first example of dinuclear V(IV) complex with O → VIV = O → VIV = O core (Cambridge Structural Database (CSD)​, version 5.42, update of May 2021). The cytotoxicity of ligands and complexes was evaluated towards ovarian (A2780), breast (MCF7) and prostate (PC3) cancer cells at 48 h. While ligands showed modest IC50 values (>42 μM), all complexes turned out to be effective in the range 3.9–17.2 μM. In particular, A2780 and MCF7 cell lines were the most sensitive to the newly synthesized V(IV)O complexes.



中文翻译:

三齿卤素取代的席夫碱的细胞毒性氧化钒 (IV) 配合物:第一个双核 V(IV) 配合物与 O → VIV = O → VIV = O 核心

潜在的 N,N,O-三齿希夫碱配体 Cl-LH、Br-LH、BrCl-LH 和 H-LH 与 [V IV O(acac) 2 ] 以 2:1 的比例在甲醇中反应得到相应的单核和双核氧化钒(IV)配合物,VO(Cl-L) 2 (1), VO(Br-L) 2 (2), [(BrCl-L) 2 (H 2 O)V(μ-O) VO(BrCl-L) 2 ] (3) 和 [(HL) 2 (H 2 O)V(μ -O)VO(HL) 2 ] (4),产率良好。通过元素分析和 FT-IR 光谱对配体和配合物进行了充分表征。配体还通过1 H NMR 光谱表征。V(IV)O 与 d 1的氧化态EPR 证实了所有合成复合物中的构型。此外,通过 X 射线衍射 (XRD) 分析确定了 2 和 3 的结构,表明它们分别为单核和双核钒 (IV) 配合物,配位体以双齿螯合物的形式配位。3 的结构代表了具有 O → V IV  = O → V IV  = O 核的双核 V(IV) 复合物的第一个例子(剑桥结构数据库 (CSD),版本 5.42,2021 年 5 月更新)。在 48 小时时评估配体和复合物对卵巢 (A2780)、乳腺癌 (MCF7) 和前列腺 (PC3) 癌细胞的细胞毒性。虽然配体显示出适度的 IC 50值 (>42 μM),结果证明所有复合物在 3.9–17.2 μM 范围内都有效。特别是 A2780 和 MCF7 细胞系对新合成的 V(IV)O 复合物最敏感。

更新日期:2021-08-12
down
wechat
bug