ABSTRACT

Introduction: Vaccine development for the disease caused by the herpes simplex virus (HSV) has been challenging over the years and is always in dire need of novel approaches for prevention and cure. To date, the HSV disease remains incurable and challenging to prevent. The disease is extremely widespread due to its high infection rate, resulting in millions of infection cases worldwide.

Areas covered: This review first explains the diverse forms of HSV-related disease presentations and reports past vaccine history for the disease. Next, this review examines current and novel HSV vaccine approaches being studied and tested for efficacy and safety as well as vaccines in clinical trial phases I to III. Modern approaches to vaccine design using bioinformatics are described. Finally, we discuss measures to enhance new vaccine development pipelines for HSV.

Expert opinion: Modernized approaches using in silico analysis and bioinformatics are emerging methods that exhibit potential for producing vaccines with enhanced targets and formulations. Although not yet fully established for HSV disease, we describe current studies using these approaches for HSV vaccine design to shed light on these methods. In addition, we provide up-to-date requirements of immunogenicity, adjuvant selection, and routes of administration.

摘要

简介：多年来，针对单纯疱疹病毒 (HSV) 引起的疾病的疫苗开发一直充满挑战，并且始终迫切需要新的预防和治疗方法。迄今为止，HSV 疾病仍然无法治愈且难以预防。该疾病由于其高感染率而极为普遍，导致全球数百万感染病例。

涵盖的领域：本综述首先解释了多种形式的 HSV 相关疾病表现，并报告了该疾病过去的疫苗接种史。接下来，本综述审查了目前和新型 HSV 疫苗方法正在研究和测试的有效性和安全性，以及临床试验 I 至 III 期的疫苗。描述了使用生物信息学设计疫苗的现代方法。最后，我们讨论了加强 HSV 新疫苗开发渠道的措施。

专家意见：使用计算机分析和生物信息学的现代化方法是新兴方法，它们显示出生产具有增强目标和配方的疫苗的潜力。虽然尚未完全确定 HSV 疾病，但我们描述了使用这些方法进行 HSV 疫苗设计的当前研究，以阐明这些方法。此外，我们还提供免疫原性、佐剂选择和给药途径的最新要求。