Rats with low-level globus pallidus (GP) dopaminergic denervation can develop anxiety without any motor alterations. The aim of this study was to evaluate the effect of low-level 6-OHDA-induced unilateral and bilateral GP lesions in male Wistar rats (n = 8/group) on recognition memory, motor activity, and the number of TH+ neurons in the SNc. For unilateral- and bilateral-lesioned animals, there was a significant decrease in the number of TH+ neurons (27% and 42%, respectively) and in the object, location, and temporal order discrimination indexes of recognition memory tests. Motor activity was unaffected. Thus, GP dopamine denervation was detrimental to short-memory.

具有低水平苍白球 (GP) 多巴胺能去神经支配的大鼠可以在没有任何运动改变的情况下发展焦虑。本研究的目的是评估低水平 6-OHDA 诱导的雄性 Wistar 大鼠（n  = 8/组）单侧和双侧 GP 损伤对识别记忆、运动活动和 TH+ 神经元数量的影响。 SNc。对于单侧和双侧损伤动物，TH+ 神经元的数量（分别为 27% 和 42%）以及识别记忆测试的对象、位置和时间顺序辨别指数显着减少。运动活动不受影响。因此，GP 多巴胺去神经对短记忆有害。