Abstract

In the present study, via using a mixed ligand synthesis approach, two new Co(II) coordination polymers (CPs) with the chemical compositions of [Co(μ₂-Hcpoia)(phen)(H₂O)]_n (1, phen = phenanthroline), and [Co₂(μ₂-Hcpoia)₂(μ₂–4,4′-bpy)(H₂O)₂]_n·2nH₂O (2, 4,4′-bpy = 4,4′-bipyridine) have been successfully prepared via reaction of Co(NO₃)₂·6H₂O with an asymmetric semirigid tricarboxylate ligand 4-(4-carboxyphenoxy)isophthalic acid (H₃cpoia) in the presence of different N-donor co-ligands. Furthermore, the treatment activity of compounds 1 and 2 against bacterial acute sinusitis was evaluated and the related mechanism was explored at the same time. First of all, the inhibitory activity of compounds 1 and 2 on the Streptococcus pneumoniae survival rate was determined with Colony-Forming Units (CFU) assay. In addition to this, the content of inflammatory cytokines released into the nasal mucus was measured with enzyme linked immunosorbent assay (ELISA) after compounds exposure.

摘要

在本研究中，通过使用混合配体合成方法，两种新的 Co(II) 配位聚合物 (CPs) 具有 [Co( μ ₂ -Hcpoia)(phen)(H ₂ O)] _n ( 1 , phen = 菲咯啉）和 [Co ₂ ( μ ₂ -Hcpoia) ₂ ( μ ₂ –4,4'-bpy)(H ₂ O) ₂ ] _n ·2nH ₂ O ( 2 , 4,4'-bpy = 4 ,4'-联吡啶)通过Co(NO ₃ ) ₂ ·6H ₂反应成功制备在不同的 N 供体共配体存在下，O 具有不对称的半刚性三羧酸配体 4-(4-羧基苯氧基)间苯二甲酸 (H ₃ cpoia)。此外，还评估了化合物1和2对细菌性急性鼻窦炎的治疗活性，同时探索了相关机制。首先，化合物1和2对肺炎链球菌存活率的抑制活性用菌落形成单位(CFU)测定法测定。除此之外，在化合物暴露后，用酶联免疫吸附试验 (ELISA) 测量释放到鼻粘液中的炎性细胞因子的含量。