Abstract

In this study, two new Co(II)-containing coordination polymers (CPs) with the chemical compositions of [Co(Hcpboda)(2,2-bipy)(H₂O)]_n (1, 2,2-bipy = 2,2-bipyridine) and {[Co₃(cpboda)₂(phen)₂(H₂O)₂]·2DMF·3H₂O}_n (2, phen = 1,10-phenanthroline) were synthesized by reaction of Co(NO₃)₂·6H₂O with the 3,3′-((5-carboxy-1,3-phenylene)bis(oxy))dibenzoic acid (H₃cpboda) in the presence of different N-donor co-ligands. The structural analysis results show that complex 1 features a zero-dimensional binuclear structure which was further extended into a 1 D chain via the H-bond interactions, while complex 2 shows a two-dimensional layered network based on the linear trinuclear [Co₃(μ_1,1-OH₂)₂(μ_1,3-COO)₆] subunits. The blood glucose meter was used to measure the blood sugar level in the Type II diabetes animal model after indicated compound treatment. Additionally, the real time reverse transcription-polymerase chain reaction (RT-PCR) was conducted and the activation levels of SAMD signaling pathway in the liver cells was measured. Above all, compound 1 was much more excellent than compound 2 on Type II diabetes treatment.

摘要

在本研究中，两种新的含 Co(II) 的配位聚合物 (CPs) 的化学组成为 [Co(Hcpboda)(2,2-bipy)(H ₂ O)] _n ( 1 , 2,2-bipy = 2,2-联吡啶)和{[Co ₃ (cpboda) ₂ (phen) ₂ (H ₂ O) ₂ ]·2DMF·3H ₂ O} _n ( 2 , phen = 1,10-菲咯啉) Co(NO ₃ ) ₂ ·6H ₂ O与3,3'-((5-羧基-1,3-亚苯基)双(氧基))二苯甲酸(H ₃cpboda) 在不同的 N 供体共配体存在下。结构分析结果表明，配合物1具有零维双核结构，通过氢键相互作用进一步扩展为一维链，而配合物2则显示出基于线性三核[Co ₃ ( μ _1,1 -OH ₂ ) ₂ (μ _1,3 -COO) ₆] 亚基。血糖仪用于在指定的化合物治疗后测量II型糖尿病动物模型中的血糖水平。此外，还进行了实时逆转录聚合酶链反应 (RT-PCR)，并测量了肝细胞中 SAMD 信号通路的激活水平。最重要的是，化合物1在 II 型糖尿病治疗方面比化合物2更出色。