ABSTRACT

In order to realise the biocompatibility and antibacterial activity of Ti alloy to meet the requirements of oral and orthopaedic applications, drug-loaded hydroxyapatite coatings doped with strontium were designed and constructed on the surface of Ti alloy using layer-by-layer assembly and hydrothermal treatment. The obtained coating was characterised by Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. The biological assays showed that the composite coating exhibited excellent biocompatibility and antibacterial activity. Therefore, based on the in vitro studies, it can be claimed that the LbL assembly and the multifunctional coating can act as a promising surface-engineering strategy for the functionalization of Ti alloy in clinical trials.

摘要

为了实现钛合金的生物相容性和抗菌活性，以满足口腔和骨科应用的要求，采用逐层组装和水热处理的方法，在钛合金表面设计并构建了掺锶载药羟基磷灰石涂层。 . 所获得的涂层通过傅里叶变换红外光谱、X射线衍射和扫描电子显微镜进行表征。生物测定表明，复合涂层表现出优异的生物相容性和抗菌活性。因此，基于体外研究，可以声称 LbL 组件和多功能涂层可以作为临床试验中钛合金功能化的有前景的表面工程策略。