The recently defined and yet rather new topic of healthy aging is attracting more attention worldwide. As the world population is getting older, it is rapidly becoming essential to develop and maintain functional abilities at older age and develop mechanisms to protect the senior population from chronic diseases. One of the most effective components, as well as processes associated with aging, is the recently discovered and Nobel prize-awarded—nitric oxide (NO) (as a signaling molecule), which, followed by later discoveries, showed to have a positive metabolic, immunological, and anti-inflammatory effect. Nitrates are one of the most debated topics of the last decade in the scientific community due to their pathways involved in the production of nitric oxide. Thus, the objective of this study is to evaluate the effect of different potassium nitrate concentrate supplementation on Drosophila melanogaster longevity imitating a human carbohydrate-based diet with relationship to possible cause of oxidative stress. Influence of 0.5–3% potassium nitrate medium on the lifespan and motor function in different groups consisting of 100 fruit fly females in each was analyzed. In this assay, female fly species supplemented with potassium nitrate diet showed life span increase by 18.6% and 5.1% with 1% and 2% KNO₃, respectively, with a positive impact on locomotor function. In conclusion, we found that low concentration of potassium nitrate medium increased lifespan and locomotor function in Drosophila melanogaster.

中文翻译：

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膳食硝酸钾对黑腹果蝇寿命的影响

最近定义的但相当新的健康老龄化主题正在引起全世界更多的关注。随着世界人口的老龄化，发展和保持老年人的功能能力以及建立保护老年人免受慢性病侵害的机制正迅速变得至关重要。最有效的成分之一，以及与衰老相关的过程，是最近发现并获得诺贝尔奖的一氧化氮 (NO)（作为信号分子），随后的发现表明它具有积极的代谢作用、免疫和抗炎作用。硝酸盐是过去十年来科学界争论最多的话题之一，因为它们参与一氧化氮的产生。因此，模仿人类碳水化合物饮食的黑腹果蝇寿命与氧化应激的可能原因有关。分析了 0.5-3% 硝酸钾培养基对由 100 只雌性果蝇组成的不同组的寿命和运动功能的影响。在该测定中，补充有硝酸钾饮食的雌性果蝇物种的寿命分别增加了 18.6% 和 5.1%，而 1% 和 2% KNO ₃对运动功能有积极影响。总之，我们发现低浓度的硝酸钾培养基增加了黑腹果蝇的寿命和运动功能。