Cushing’s disease is a rare endocrine condition in which a pituitary corticotroph adenoma drives excess adrenal cortisol production, and is one cause of endogenous Cushing’s syndrome. We present a young woman with 3 weeks of headaches and cognitive disturbance who subsequently developed florid psychosis requiring multiple admissions under neurology and psychiatry. Her clinical stigmata of hypercortisolism and biochemical abnormalities prompted an MR scan of the pituitary, which confirmed a pituitary microadenoma. Treatment with metyrapone and subsequent surgery led to complete recovery within 2 months. Cushing’s disease commonly causes neuropsychiatric symptoms and can present with psychosis. Diagnosing Cushing’s disease can be challenging, but with early diagnosis and treatment it has an excellent prognosis.

中文翻译：

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库欣病表现为精神病

库欣病是一种罕见的内分泌疾病，垂体促肾上腺皮质激素腺瘤导致肾上腺皮质醇产生过多，并且是内源性库欣综合征的一个原因。我们介绍了一名患有 3 周头痛和认知障碍的年轻女性，她随后出现了需要多次入院接受神经病学和精神病学治疗的重度精神病。她的皮质醇增多症和生化异常的临床特征促使对垂体进行 MR 扫描，证实了垂体微腺瘤。用美替拉酮治疗和随后的手术导致在 2 个月内完全康复。库欣病通常会导致神经精神症状，并可能出现精神病。诊断库欣病可能具有挑战性，但通过早期诊断和治疗，其预后良好。