Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease,Neuropathology and Applied Neurobiology

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Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-07-23 , DOI: 10.1111/nan.12753
Lucía Viejo _{1,

2,

3} , Ayush Noori _{1,

2,

4,

5,

6} , Emily Merrill _{1,

2,

5} , Sudeshna Das _{1,

2,

5,

6,

7} , Bradley T Hyman _{1,

2,

6,

7} , Alberto Serrano-Pozo _{1,

2,

6,

7}

Affiliation

Reactive astrocytes in Alzheimer's disease (AD) have traditionally been demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however, astrocyte reaction is a complex and heterogeneous phenomenon involving multiple astrocyte functions beyond cytoskeletal remodelling. To better understand astrocyte reaction in AD, we conducted a systematic review of astrocyte immunohistochemical studies in post-mortem AD brains followed by bioinformatics analyses on the extracted reactive astrocyte markers.

中文翻译：

对人类死后免疫组织化学研究和生物信息学分析的系统评价揭示了阿尔茨海默病星形胶质细胞反应的复杂性

阿尔茨海默病 (AD) 中的反应性星形胶质细胞传统上表现为胶质纤维酸性蛋白 (GFAP) 免疫反应性增加；然而，星形胶质细胞反应是一种复杂且异质的现象，涉及除细胞骨架重塑之外的多种星形胶质细胞功能。为了更好地了解 AD 中的星形胶质细胞反应，我们对死后 AD 大脑中的星形胶质细胞免疫组织化学研究进行了系统评价，然后对提取的反应性星形胶质细胞标记物进行了生物信息学分析。

更新日期：2021-07-23

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