Abstract

The survey was carried out to study the effects of the Argovite medication and dimethyl sulfoxide on the morphological, biochemical, and immunological blood parameters of cows with postpartum purulent-catarrhal endometritis in the block-calving period in Novosibirsk oblast in 2019–2020. In order to perform the surveys, three groups of 50 animals each were allocated. The first group was control, composed of healthy specimens. The two other groups involving the cows with postpartum purulent-catarrhal endometritis were experimental. The medication composed of argovite 10% water solution combined with dimethyl sulfoxide 5% water solution was administered intrauterine in specimens of the first experimental group at a dose of 0.3 mL/kg liveweght every 48 h up to the disappearance of clinical symptoms of a disease. In addition, an intramuscular injection of uteroton was administered once at a dose of 0.02 mL/kg liveweight. With respect to the cows of the second experimental group, cod liver oil (0.3 mL/kg liveweight), in combination with oxytetracycline hydrochloride (40 mg/kg liveweight), was administered intrauterine every 48 h. In addition, an intramuscular injection of uteroton at a dose of 0.02 mL/kg liveweight was administered once. After the treatment of cows with postpartum purulent-catarrhal endometritis in the first experimental group, insignificant increases in phagocytic activity, phagocytic index, and phagocytic number were recorded, which were higher by 1.3, 1.4, and 4.9%, respectively, relative to the reference values before the treatment. With respect to the cows of the second experimental group, a decline in the parameter values by 1.3, 8.4, and 9.0%, respectively, was observed. The outcomes of the blood hematology and biochemistry surveys during the treatment of bovine postpartum purulent-catarrhal endometritis with the medication containing argovite 10% water solution combined with dimethyl sulfoxide 5% water solution have proven the absence of its negative effects on the main physiological parameters.

中文翻译：

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含银和二甲基亚砜纳米颗粒的复方药物对产后化脓性-卡他性子宫内膜炎奶牛血液参数的影响，评估治疗效果

摘要

开展这项调查是为了研究 Argovite 药物和二甲基亚砜对 2019-2020 年新西伯利亚州产后产后化脓性卡他性子宫内膜炎母牛的形​​态学、生化和免疫学血液参数的影响。为了进行调查，分配了三组，每组 50 只动物。第一组是对照组，由健康标本组成。涉及产后化脓性卡他性子宫内膜炎奶牛的另外两组是实验性的。第一实验组标本宫腔内给予鹅卵石10%水溶液联合二甲亚砜5%水溶液，剂量为0.3 mL/kg活体重，每48 h一次，直至疾病临床症状消失。此外，以 0.02 mL/kg 活体重的剂量肌肉注射一次 uteroton。对于第二实验组的奶牛，每48小时宫内注射一次鱼肝油（0.3 mL/kg活重）和盐酸土霉素（40 mg/kg活重）。此外，以0.02mL/kg活体重的剂量肌内注射子宫胎素一次。第一实验组母牛产后化脓性卡他性子宫内膜炎治疗后，吞噬细胞活性、吞噬指数和吞噬细胞数均无显着增加，分别比参照组高1.3%、1.4%和4.9%治疗前的值。对于第二个实验组的奶牛，参数值下降了 1.3%、8.4% 和 9.0%，分别进行了观察。用含阿戈维特10%水溶液联合二甲亚砜5%水溶液的药物治疗牛产后化脓性-卡他性子宫内膜炎期间的血液学和生化调查结果证明其对主要生理参数没有负面影响。