The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex,Cell Proliferation

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The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-07-23 , DOI: 10.1111/cpr.13101
Jianqiang Chen ₁ , Xiangxiang Jin ₁ , Yanan Mei ₁ , Zhe Shen ₁ , Jufan Zhu ₁ , Hongyi Shi ₁ , Minshan Wang _{2,

3} , Xiaohui Zheng ₁ , Guang Liang _{1,

4}

Affiliation

Osteosarcoma (OS) is characterized by high levels of the tumour-associated inflammatory microenvironment. Moreover, in approximately 60% of OS, telomere length is maintained by alternative lengthening of telomeres (ALT) pathway. Whether the ALT pathway can be exploited for OS therapeutic treatment and how the OS inflammatory microenvironment influences the anti-cancer drug effect remains unknown. Here, we examined the biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of OS cells.

中文翻译：

TMPyP4和顺铂在骨肉瘤炎症微环境中的不同生物学效应归因于G-四链体

骨肉瘤（OS）的特点是高水平的肿瘤相关炎症微环境。此外，在大约 60% 的 OS 中，端粒长度是通过端粒选择性延长 (ALT) 途径来维持的。ALT通路是否可以用于OS治疗以及OS炎症微环境如何影响抗癌药物作用仍不清楚。在这里，我们检查了 TMPyP4 和顺铂在 OS 细胞炎症微环境中的生物学效应。

更新日期：2021-09-20

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