Pecans are a rich source of antioxidants, but the effect of regular consumption on post-meal responses is unknown. The objective of this study was to examine the impact of daily pecan consumption for 8 weeks on fasting and postprandial lipid peroxidation, total antioxidant capacity (TAC), and tocopherols in adults at higher risk for cardiovascular disease (CVD) (hypercholesterolemia or elevated adiposity). We hypothesized that daily pecan consumption would result in increased fasting γ-tocopherol, increased fasting and postprandial TAC, and decreased fasting and postprandial lipid peroxidation. This was a randomized, parallel, controlled trial with 3 treatments: two pecan groups and a nut free control (n = 16). The ADD group (n = 15) consumed pecans as part of a free-living diet, and the SUB group (n = 16) substituted the pecans for isocaloric foods from their habitual diet. At the pre- and post-intervention, a high saturated fat breakfast shake was consumed with postprandial blood draws over 2h. In the ADD and SUB groups, postprandial lipid peroxidation was suppressed (iAUC: 0.9 ± 1.3 to -2.9 ± 2.0 and 4.5 ± 1.7 to 0.7 ± 1.1 µM/2h, respectively; P <0.05) and TAC was elevated (iAUC: -240.8 ± 110.2 to 130.9 ± 131.7 and -227.6 ± 131.2 to 208.7 ± 145.7 µM Trolox Equivalents/2h, respectively; P <0.01) from pre- to post-intervention. Furthermore, there was an increase in γ-tocopherol from pre- to post-intervention within the ADD (1.4 ± 0.1 to 1.8 ± 0.1 µg/mL; P <0.001) and SUB groups (1.8 ± 0.2 to 2.1 ± 0.2 µg/mL; P <0.05). There were no changes in any variable within the control group. These findings suggest that daily pecan consumption protects against oxidative stress that occurs following a high-fat meal in adults at risk for CVD.

山核桃是抗氧化剂的丰富来源，但经常食用对餐后反应的影响尚不清楚。本研究的目的是检查 8 周内每天食用山核桃对心血管疾病 (CVD) 高风险（高胆固醇血症或肥胖升高）成人的空腹和餐后脂质过氧化、总抗氧化能力 (TAC) 和生育酚的影响. 我们假设每天食用山核桃会导致空腹 γ-生育酚增加，空腹和餐后 TAC 增加，并减少空腹和餐后脂质过氧化。这是一项随机、平行、对照试验，包含 3 种治疗：两个山核桃组和一个无坚果对照 ( n  = 16)。ADD 组 ( n = 15）食用山核桃作为自由生活饮食的一部分，SUB 组（n  = 16）用山核桃代替他们习惯性饮食中的等热量食物。在干预前和干预后，高饱和脂肪早餐奶昔与餐后抽血超过 2 小时一起食用。在 ADD 和 SUB 组中，餐后脂质过氧化受到抑制（iAUC：分别为 0.9 ± 1.3 至 -2.9 ± 2.0 和 4.5 ± 1.7 至 0.7 ± 1.1 µM/2h；P <0.05）和 TAC 升高（iAUC：-240.8 ± 110.2 至 130.9 ± 131.7 和 -227.6 ± 131.2 至 208.7 ± 145.7 µM Trolox 等效物/2 小时；从干预前到干预后， P <0.01)。此外，在 ADD 内，从干预前到干预后，γ-生育酚增加（1.4 ± 0.1 至 1.8 ± 0.1 µg/mL；P<0.001) 和 SUB 组 (1.8 ± 0.2 至 2.1 ± 0.2 µg/mL; P <0.05)。对照组内的任何变量都没有变化。这些研究结果表明，每天食用山核桃可以保护有心血管疾病风险的成年人在高脂肪餐后发生的氧化应激。