Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.

中文翻译：

---

利用脂毒性治疗肝癌

代谢改变经常发生在实体瘤中，但代谢性癌症治疗受到代谢网络的复杂性和可塑性的限制。我们最近可以证明，肝脏 X 受体 α (LXRα) 的激活和 Raf-1-SCD1 蛋白复合物的抑制诱导饱和游离脂肪酸的细胞内积累，导致肿瘤细胞中的致死性脂毒性，并允许有效治疗肝脏癌。