The treatment paradigm for borderline and locally advanced pancreatic cancer is evolving with an increased shift towards utilising systemic chemotherapy and chemoradiation to potentially facilitate more curative resections. This has been driven by the improved outcomes from the use systemic combination chemotherapy on its own, or sequentially with chemoradiation, resulting in improved resection rates and survival outcomes.

中文翻译：

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优化边缘性和局部晚期胰腺癌的治疗途径：适应性个性化方法

交界性和局部晚期胰腺癌的治疗模式正在不断发展，越来越多地转向利用全身化疗和放化疗，以潜在地促进更有效的切除。这是由于单独使用全身联合化疗或序贯放化疗改善了结果，从而提高了切除率和生存结果。