Enzymatic Asymmetric Reduction of Unfunctionalized C=C Bonds with Archaeal Geranylgeranyl Reductases,ChemBioChem

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Enzymatic Asymmetric Reduction of Unfunctionalized C=C Bonds with Archaeal Geranylgeranyl Reductases
ChemBioChem ( IF 2.6 ) Pub Date : 2021-07-22 , DOI: 10.1002/cbic.202100290
Richard Cervinka ₁ , Daniel Becker _{1,

2} , Steffen Lüdeke ₁ , Sonja-Verena Albers ₃ , Thomas Netscher ₄ , Michael Müller ₁

Affiliation

Archaeal geranylgeranyl reductases were tested for the biocatalytic asymmetric reduction of isolated unfunctionalized C=C bonds. The reduction of acyclic terpene chains with different head groups showed great tolerance for substrates, without affecting cyclic or terminal C=C bonds. Moreover, the introduction of a succinate hemiester significantly increased conversion. The reaction is highly diastereo- and enantioselective (ee>99 %).

中文翻译：

使用古菌香叶基香叶基还原酶对未功能化的 C=C 键进行酶促不对称还原

测试了古菌香叶基香叶基还原酶对分离的未功能化 C=C 键的生物催化不对称还原。具有不同头基的无环萜烯链的还原对底物表现出极大的耐受性，而不影响环状或末端C=C键。此外，琥珀酸酯半酯的引入显着提高了转化率。该反应具有高度非对映选择性和对映选择性 ( ee >99 %)。

更新日期：2021-09-02

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