Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.

中文翻译：

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用红光控制血液凝固

在许多临床情况下，精确控制凝血和快速逆转抗凝是必不可少的。我们通过 Cu 催化的点击化学，成功地用源自 Cy7 的红光光裂解接头修饰了凝血酶结合适体。我们能够证明，即使在人类血液中，我们也可以使用红光 (660 nm) 成功灭活修饰的适体——恢复血液的自然凝固能力。