Pipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed. The compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis. The results suggested oxygen atoms present at carbonyl and carboxylic group render the bidentate6 property to the pipemidic acid. The antimicrobial activity of the compounds was determined by the disk diffusion method, and both standard and complexes show no antibacterial activity against the clinical isolates.

中文翻译：

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哌啶酸金属配合物的合成、表征和抗菌研究

哌啶酸与其他喹诺酮类药物一样，在体外对不同微生物敏感，已被证明是某些适应症的首选。先前的研究表明，必需元素和微量元素与喹诺酮类药物同时使用会降低胃肠道吸收，导致治疗失败。为了研究哌啶酸与人体内必需元素和微量元素的可能相互作用，哌啶酸已与镁、钙、铬、锰、铁、钴、镍、铜、锌和镉反应，形成复合物。这些化合物的特征在于熔点、电导研究、IR、UV、1H-NMR、CHN 和原子吸收分析。结果表明存在于羰基和羧基上的氧原子使哌啶酸具有双齿 6 特性。