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NMR spectroscopy charges into protein surface electrostatics [Biophysics and Computational Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2021-07-27 , DOI: 10.1073/pnas.2110176118
Frans A A Mulder 1
Affiliation  

Life needs interaction. The current pandemic has made visible how much interaction, or lack thereof, means for the life of each and every one of us. The validity of this statement also extends to the tiny and invisible: Over the years, scientists have taken key steps to understand the interactions that are vital to life, and that take place on the molecular scale. This field of “biomolecular interactions” is of enormous importance, as it describes the perpetual and correct dynamic functioning of all the components inside living cells, and whose understanding is at the heart of human diseases and underpins how drugs act on their targets. Therefore, the study of molecular interactions is as essential as it is a vital scientific endeavor.

中文翻译:

核磁共振波谱向蛋白质表面静电充电 [生物物理学和计算生物学]

生活需要互动。当前的大流行已经表明,互动或缺乏互动对我们每个人的生活意味着多少。这一说法的有效性也延伸到了微小和不可见的事物:多年来,科学家们已经采取了关键步骤来了解对生命至关重要的相互作用,以及发生在分子尺度上的相互作用。这个“生物分子相互作用”领域非常重要,因为它描述了活细胞内所有成分的永久和正确的动态功能,对人类疾病的理解是人类疾病的核心,也是药物如何作用于其靶点的基础。因此,分子相互作用的研究既是一项重要的科学努力,也是必不可少的。
更新日期:2021-07-23
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