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Association between coronary artery calcium score on non-contrast chest computed tomography and all-cause mortality among patients with congestive heart failure
Heart and Vessels ( IF 1.5 ) Pub Date : 2021-07-22 , DOI: 10.1007/s00380-021-01906-y
Kyoko Ota 1 , Rine Nakanishi 1 , Hidenobu Hashimoto 2 , Yuriko Okamura 1 , Ippei Watanabe 2 , Takayuki Yabe 2 , Ryo Okubo 2 , Takanori Ikeda 1
Affiliation  

Coronary artery calcium (CAC) score is a robust prognostic tool to predict cardiac events. Although patients with congestive heart failure (CHF) occasionally undergo non-contrast computed tomography (NCCT), the prognostic utility of CAC by NCCT is not widely known. We aimed to determine if CAC measured on NCCT is associated with all-cause mortality (ACM) among patients with CHF. We identified 550 patients admitted due to CHF who underwent NCCT. Patients were categorized into three groups according to CAC scores 0, 1–999, and ≥ 1000. The multivariate Cox proportional hazards model was used to assess if CAC by NCCT was associated with ACM after adjusting for traditional coronary artery disease (CAD) risk factors, brain natriuretic peptide and left ventricular ejection fraction (LVEF). In a subset of 245 patients with invasive coronary angiography (ICA), the associations between CAC scores and ACM were assessed in the multivariate Cox proportional hazards model. Further, we assessed if CAC increased statin use at discharge. During a mean follow-up of 3.3 ± 3.1 years, ACM occurred in 168 patients (30.55%). Compared with patients with CAC 0, those with CAC ≥ 1000 (HR 1.564, 95% CI 0.969–2.524, P = 0.067) were more likely to experience ACM, while those with CAC score 1–999 (HR 0.971, 95% CI 0.673–1.399, P = 0.873) were not. Similarly, a trend toward significance was observed in patients with LVEF < 40% (HR 2.124, 95% CI 0.929–4.856, P = 0.074). In the sub-analysis, patients with CAC ≥ 1000 had increased ACM compared to those with CAC 0, only if ICA ≥ 50% (HR 3.668, 95% CI 1.141–11.797, P = 0.029). Multivariate logistic regression revealed that statin use at discharge was increased with ICA ≥ 50%, but not CAC. The CAC score measured by NCCT tended to be associated with ACM among CHF patients. Statin use was not increased by CAC on NCCT.



中文翻译:

非对比胸部计算机断层扫描冠状动脉钙化评分与充血性心力衰竭患者全因死亡率的关系

冠状动脉钙化 (CAC) 评分是预测心脏事件的有力预后工具。尽管充血性心力衰竭 (CHF) 患者偶尔会接受非对比计算机断层扫描 (NCCT),但 NCCT 对 CAC 的预后效用并不广为人知。我们旨在确定在 NCCT 上测量的 CAC 是否与 CHF 患者的全因死亡率 (ACM) 相关。我们确定了 550 名因 CHF 入院并接受 NCCT 的患者。根据 CAC 评分 0、1-999 和 ≥ 1000 将患者分为三组。在调整传统冠状动脉疾病 (CAD) 危险因素后,使用多变量 Cox 比例风险模型评估 NCCT 的 CAC 是否与 ACM 相关、脑利钠肽和左心室射血分数(LVEF)。在 245 名有创冠状动脉造影 (ICA) 患者的子集中,在多变量 Cox 比例风险模型中评估了 CAC 评分和 ACM 之间的关联。此外,我们评估了 CAC 是否增加了出院时他汀类药物的使用。在 3.3 ± 3.1 年的平均随访期间,168 名患者 (30.55%) 发生 ACM。与 CAC 0 的患者相比,CAC ≥ 1000 的患者 (HR 1.564, 95% CI 0.969–2.524,P  = 0.067)更有可能经历 ACM,而 CAC 评分为 1-999 的人(HR 0.971, 95% CI 0.673-1.399, P  = 0.873)则没有。同样,在 LVEF < 40% 的患者中观察到显着性趋势(HR 2.124, 95% CI 0.929–4.856, P  = 0.074)。在子分析中,仅当 ICA ≥ 50% 时,CAC ≥ 1000 的患者与 CAC 0 的患者相比 ACM 增加(HR 3.668,95% CI 1.141–11.797,P  = 0.029)。多变量逻辑回归显示出院时他汀类药物的使用随着 ICA ≥ 50% 而增加,但 CAC 没有增加。在 CHF 患者中,通过 NCCT 测量的 CAC 评分往往与 ACM 相关。CAC 在 NCCT 上没有增加他汀类药物的使用。

更新日期:2021-07-22
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