Objectives To investigate association between latency after preterm premature rupture of membranes (PPROM) and perinatal outcomes at moderately and late preterm gestation. Methods National perinatal registry-based cohort study using data for the period 2013–2018. Singleton pregnancies with non-malformed fetuses in cephalic presentation complicated by PPROM at 32+0–36+6 weeks were included. Associations between latency period and perinatal mortality, neonatal respiratory distress syndrome (RDS), early onset neonatal infection (EONI), and cesarean section were assessed using multiple logistic regression, adjusting for potential confounders (labor induction, maternal body-mass-index, maternal age, antenatal corticosteroids, and small-for-gestational-age). p<0.05 was considered statistically significant. Results Of 3,017 pregnancies included, 365 (12.1%) had PPROM at 32+0–33+6 weeks and 2,652 (87.9%) at 34+0–36+6 weeks. Among all cases, 2,540 (84%) had latency <24 h (group A), 305 (10%) 24–47 h (group B), and 172 (6%) ≥48 h (group C). Longer latency was associated with higher incidence of EONI (adjusted odds ratio [aOR] 1.350; 95% confidence interval [CI] 0.900–2.026 for group B and aOR 2.500; 95% CI 1.599–3.911 for group C) and higher rate of caesarean section (aOR 2.465; 95% CI 1.763–3.447 for group B and aOR 1.854; 95% CI 1.172–2.932 for group C). Longer latency was not associated with rates of RDS (aOR 1.160; 95% CI 0.670–2.007 for group B and aOR 0.917; 95% CI 0.428–1.966 for group C). Conclusions In moderately to late PPROM, increased latency is associated with higher risk of EONI and cesarean section with no reduction in RDS.

中文翻译：

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妊娠 32-37 周胎膜早破后潜伏期与围产期结局的关联：一项基于围产期登记的队列研究

目的 研究早产胎膜早破 (PPROM) 后潜伏期与中度和晚期早产妊娠围产期结局之间的关联。方法 使用 2013-2018 年期间的数据进行的基于国家围产期登记的队列研究。32岁时头先露的非畸形胎儿单胎妊娠并发PPROM+0–36+6周被包括在内。使用多元逻辑回归评估潜伏期与围产期死亡率、新生儿呼吸窘迫综合征 (RDS)、早发型新生儿感染 (EONI) 和剖宫产之间的关联，并调整潜在的混杂因素（引产、产妇体重指数、产妇年龄、产前皮质类固醇和小于胎龄儿）。p<0.05 被认为具有统计学意义。结果 在 3,017 例妊娠中，365 例 (12.1%) 的 PPROM 为 32+0–33+6周和 2,652 (87.9%) 在 34+0–36+6周。在所有病例中，2,540 (84%) 例潜伏期<24 小时（A 组），305 例（10%）24-47 小时（B 组），172 例（6%）≥48 小时（C 组）。更长的潜伏期与更高的 EONI 发生率相关（调整后的优势比 [aOR] 1.350；B 组的 95% 置信区间 [CI] 0.900-2.026 和 aOR 2.500；C 组的 95% CI 1.599-3.911）和更高的剖宫产率部分（aOR 2.465；B 组 95% CI 1.763–3.447 和 aOR 1.854；C 组 95% CI 1.172–2.932）。较长的潜伏期与 RDS 的发生率无关（aOR 1.160；B 组的 95% CI 0.670-2.007 和 aOR 0.917；C 组的 95% CI 0.428-1.966）。结论 在中晚期 PPROM 中，潜伏期延长与 EONI 和剖宫产风险增加相关，而 RDS 没有降低。