Abstract

This article reviews current multistep synthesis strategies of azole-based antibacterial agents. In recent years, extensive use of chemical agents in treating different diseases resulted in the development of drug resistance. The war on multidrug resistance has resulted in the most significant loss to the world’s economy. Thus, the expansion of development of novel and potential candidates such as azoles and its derivatives is an escalating area in the field of medicinal chemistry. Azole compounds are increasingly being considered necessary in drug discovery paradigms as a number of them serve as lead compounds for the discovery of potent therapeutic agents. They have been used to treat bacterial, fungal, malarial, viral, and other general infections. They have also been known for their anticancer and anti-inflammatory activities. Their efficacy has been attributed to their electron-rich property, resulting in the formation of non-covalent bonds to the receptor proteins. Current research has given us a significant collection of synthetic strategies in the progress of azole compounds. This review article describes the survey of literature regarding multistep synthetic methods in the preparation of azole-based compounds and their antibacterial properties in the last 5 years.

摘要

本文回顾了目前唑类抗菌剂的多步合成策略。近年来，化学药剂在治疗不同疾病中的广泛使用导致了耐药性的发展。多药耐药性战争给世界经济造成了最重大的损失。因此，扩大开发新的和潜在的候选物如唑类及其衍生物是药物化学领域的一个不断升级的领域。唑类化合物越来越多地被认为在药物发现范例中是必要的，因为它们中的许多可作为发现有效治疗剂的先导化合物。它们已被用于治疗细菌、真菌、疟疾、病毒和其他一般感染。它们还因其抗癌和抗炎活性而闻名。它们的功效归因于它们的富电子特性，导致与受体蛋白形成非共价键。目前的研究为我们提供了一系列重要的唑类化合物合成策略。这篇综述文章描述了过去 5 年中关于制备唑类化合物的多步合成方法及其抗菌性能的文献调查。