Current Biology ( IF 8.1 ) Pub Date : 2021-07-22 , DOI: 10.1016/j.cub.2021.06.047 Jonathan R Lovas 1 , Rafael Yuste 1
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Although much is known about how the structure of the nervous system develops, it is still unclear how its functional modularity arises. A dream experiment would be to observe the entire development of a nervous system, correlating the emergence of functional units with their associated behaviors. This is possible in the cnidarian Hydra vulgaris, which, after its complete dissociation into individual cells, can reassemble itself back together into a normal animal. We used calcium imaging to monitor the complete neuronal activity of dissociated Hydra as they reaggregated over several days. Initially uncoordinated neuronal activity became synchronized into coactive neuronal ensembles. These local modules then synchronized with others, building larger functional ensembles that eventually extended throughout the entire reaggregate, generating neuronal rhythms similar to those of intact animals. Global synchronization was not due to neurite outgrowth but to strengthening of functional connections between ensembles. We conclude that Hydra’s nervous system achieves its functional reassembly through the hierarchical modularity of neuronal ensembles.
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中文翻译：
Hydra 神经系统重组中的整体同步
尽管对神经系统的结构是如何发展的了解很多，但仍不清楚其功能模块性是如何产生的。一个梦想的实验将是观察神经系统的整个发展，将功能单元的出现与其相关行为联系起来。这在刺胞动物Hydra vulgaris中是可能的，它在完全解离成单个细胞后，可以重新组装成正常动物。我们使用钙成像来监测解离Hydra的完整神经元活动因为他们在几天内重新聚集。最初不协调的神经元活动同步成协同的神经元集合。然后这些局部模块与其他模块同步，构建更大的功能集合，最终延伸到整个再聚集体，产生类似于完整动物的神经元节律。全球同步不是由于神经突的生长，而是由于加强了整体之间的功能联系。我们得出结论，Hydra的神经系统通过神经元集合的层次模块化实现其功能重组。
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