Dynamic susceptibility contrast (DSC)-MRI is a perfusion imaging technique from which useful quantitative imaging biomarkers can be derived. Relative cerebral blood volume (rCBV) is such a biomarker commonly used for evaluating brain tumors. To account for the extravasation of contrast agents in tumors, post-processing leakage correction is often applied to improve rCBV accuracy. Digital reference objects (DRO) are ideal for testing the post-processing software, because the biophysical model used to generate the DRO can be matched to the one that the software uses. This study aims to develop DROs to validate the leakage correction of software using Weisskoff model and to examine the effect of background signal time curves that are required by the model.

中文翻译：

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用于带泄漏校正的测试软件的动态磁化率对比 MRI 数字参考对象：背景模拟的影响

动态磁敏感对比 (DSC)-MRI 是一种灌注成像技术，可以从中导出有用的定量成像生物标志物。相对脑血容量 (rCBV) 是一种常用于评估脑肿瘤的生物标志物。考虑到造影剂在肿瘤中的外渗，通常应用后处理泄漏校正来提高 rCBV 的准确性。数字参考对象 (DRO) 是测试后处理软件的理想选择，因为用于生成 DRO 的生物物理模型可以与软件使用的模型相匹配。本研究旨在开发 DRO 以验证使用 Weisskoff 模型的软件泄漏校正，并检查模型所需的背景信号时间曲线的影响。