Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain,Macromolecular Rapid Communications

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Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2021-07-22 , DOI: 10.1002/marc.202100274
Shigehito Osawa ₁ , Kenichi Kitanishi ₂ , Maho Kiuchi ₃ , Motoyuki Shimonaka _{2,

3} , Hidenori Otsuka _{1,

3,

4}

Affiliation

Copper complexes act as catalysts for redox reactions to generate reactive oxygen species that destroy biomolecules and, therefore, are utilized to design drugs including antitumor and antibacterial medicines. Especially, catalytic reaction for hydrogen peroxide decomposition is important because it includes the process for generating highly toxic hydroxyl radical, i.e., Fenton-like reaction. Considering that multicoppers/hydrogen peroxide species are the important intermediates for the redox reaction, herein a polymer having copper complexes in the side chains is designed to facilitate the formation of the intermediates by building locally concentrated state of the copper complexes. The polymer increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species’ generation, eventually leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of catalysts on polymers toward drug design with low amounts of transition metals.

中文翻译：

通过在聚合物链上使用局部浓缩状态的铜催化剂加速过氧化氢的氧化还原反应

铜配合物作为氧化还原反应的催化剂，产生破坏生物分子的活性氧，因此可用于设计包括抗肿瘤和抗菌药物在内的药物。特别是过氧化氢分解的催化反应很重要，因为它包括产生剧毒羟基自由基的过程，即类芬顿反应。考虑到多铜/过氧化氢物质是氧化还原反应的重要中间体，此处设计了侧链中具有铜配合物的聚合物以通过建立铜配合物的局部浓缩状态来促进中间体的形成。该聚合物增加了它们对过氧化氢分解的催化活性并促进了活性氧的产生，最终导致更高的抗菌活性。这揭示了在聚合物上构建局部集中状态的催化剂以实现具有少量过渡金属的药物设计的优点。

更新日期：2021-08-20

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