Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.,Chemistry & Biodiversity

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Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-07-22 , DOI: 10.1002/cbdv.202100517
Min Fan _{1,

2} , Ting Wang ₃ , Li-Yan Peng ₁ , Jun-Shang Huang ₃ , Xing-De Wu ₁ , He-Yao Wang ₃ , Qin-Shi Zhao ₁

Affiliation

A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2–7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (¹H, ¹³C, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).

中文翻译：

来自西班牙鼠尾草地上部分的具有体内降血糖作用的新克罗丹二萜类化合物。

一种新的新-clerodane二萜，salvihispin H（1），和六个公知的（2 - 7）从地上部分识别西班牙鼠尾草L.的结构和绝对构型1通过光谱的广泛分析（阐明^1个ħ 、¹³ C 和 2D NMR，以及 HR-ESI-MS) 和单晶 X 射线衍射数据。在糖尿病db/db小鼠中评估了 Salvihispin H ( 1 ) 和 Salvifaricin ( 2 )的抗糖尿病作用。数据表明1和2能显着降低空腹血糖水平，改善胰岛素抵抗，化合物1的降糖作用比二甲双胍更快。此外，1和2还可以降低db/db小鼠的血清TG水平。这些结果表明，化合物1和2可被视为治疗 2 型糖尿病 (T2DM) 的有效候选物。

更新日期：2021-09-13

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