miR-485's anti-drug resistant epilepsy effects by regulating SV2A/PSD-95 and targeting ABCC1 and neuronal signaling-transduction proteins in hippocampus of rats,Brain and Behavior

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miR-485's anti-drug resistant epilepsy effects by regulating SV2A/PSD-95 and targeting ABCC1 and neuronal signaling-transduction proteins in hippocampus of rats
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-07-21 , DOI: 10.1002/brb3.2247
Kaixuan Wang ₁ , Jing Wu ₂ , Jiangping Wang ₃ , Kewen Jiang ₂

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Drug-resistant epilepsy (DRE), most subsequently developing refractory epilepsy, causes a significant burden to the society. microRNAs have been demonstrated as key regulators and therapeutic targets in epilepsy. Accordingly, the aim of the present study was to test whether miR-485 could be a potential target for DRE.

中文翻译：

miR-485通过调控SV2A/PSD-95并靶向大鼠海马ABCC1和神经元信号转导蛋白的抗耐药性癫痫作用

耐药性癫痫（DRE），大多数随后发展为难治性癫痫，给社会带来了巨大的负担。microRNA 已被证明是癫痫的关键调节因子和治疗靶点。因此，本研究的目的是测试 miR-485 是否可以成为 DRE 的潜在目标。

更新日期：2021-09-03

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