Genome-wide epistatic interactions of litter size at birth in Chinese indigenous pigs,Animal Genetics

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Genome-wide epistatic interactions of litter size at birth in Chinese indigenous pigs
Animal Genetics ( IF 1.8 ) Pub Date : 2021-07-21 , DOI: 10.1111/age.13120
Z Chen ₁ , Y Li ₁ , Z Zhang _{1,

2} , W Zhao ₂ , Z Zhang ₁ , Y Xiang ₃ , Q Wang ₁ , Y Pan ₁ , X Guo ₁ , Z Wang ₁

Affiliation

Improving litter size at birth (TNB) and the number of piglets born alive (NBA) are the main breeding goals related to litter traits, which are economically important. A better understanding of genetic architecture underlying TNB and NBA traits could increase pig production efficiency. However, most previous studies on these traits focus on additive genetic effects, while epistatic interactions underlying TNB and NBA traits has not yet been well investigated, which are essential to understand how traits-related genes interact. Herein, we conducted genome scans of epistatic interactions underlying TNB and NBA traits in a total of 150 Chinese indigenous pigs (75 Jinhua and 75 Shengxian Spotted pigs) with high throughput genomic data. Based on SNPs with high interaction values and connectivity scores, we identified eight promising candidate genes (AKT2, TSC1, MTOR, PIK3R5, TIAM1, FGF14, RALB and ROR2) potentially associated with litter traits in pigs. Moreover, the underlying pathways, e.g., calcium ion transport, pointed out their roles in litter size-related traits. Our findings provide new insight into genetic architecture of litter traits in pigs and will benefit economic profits in pig production.

更新日期：2021-09-06

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