Large-clearance TiO₂ nanotube arrays (LTAs) were synthesized by anodization, and evenly distributed P25 nanoparticles (P25 NPs) decorated on this were prepared by the hydrothermal treatment. The effect of P25 concentrations on the morphology of LATs was studied. LTAs decorated with P25 NPs (LTAs-P25) were loaded with ibuprofen (IBU), and the release properties were investigated. Interestingly, P25 NPs were successfully decorated on the surface of LTAs, with an optimal concentration of  M. The total amount of drug released from LTAs increased by 49.5% compared to that from TiO₂ nanotube arrays without large clearance. LTAs-P25 provided a lower burst and longer release time.

中文翻译：

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P25纳米粒子修饰的大间隙TiO2纳米管阵列的药物释放效应

通过阳极氧化合成了大间隙TiO ₂纳米管阵列（LTAs），并通过水热处理制备了装饰在其上的均匀分布的P25纳米颗粒（P25 NPs）。研究了 P25 浓度对 LAT 形态的影响。用 P25 NPs (LTAs-P25) 装饰的 LTA 装载有布洛芬 (IBU)，并研究了释放特性。有趣的是，P25 NPs 成功地装饰在 LTAs 表面，最佳浓度为 M.与没有大间隙的TiO ₂纳米管阵列相比，LTA释放的药物总量增加了49.5% 。LTAs-P25 提供了更低的突发和更长的释放时间。