The identification of biomarkers plays an important role in the diagnosis and prognosis of cancers. In this study, we explored the diagnostic and prognostic value of the FLAD1 expression across pan-cancer analysis from online databases (Oncomine, cBioPortal, Breast Cancer Gene-Expression Miner, UALCAN, GEO, BCIP, TNMplot, ENCORI, Kaplan-Meier Plotter, and LinkedOmics). We found that FLAD1 was overexpressed in a number of different kinds of cancers, especially in breast cancer, and higher FLAD1 expression level was associated with the HER+, p53 mutant, node-involved, NPI stage 3, basal-like, and triple-negative groups compared with the other subgroups of breast cancer. The FLAD1 expression levels were higher in patients that were 21–40 years old than those in patients of other ages and were higher in the African-American group than in the Caucasian group. We also analyzed the FLAD1-related microRNAs and their prognostic values in breast cancer. This study highlights the significance of FLAD1 in cancers and provides evidence for its potential as a biomarker for the diagnosis and prognosis of cancers.

中文翻译：

---

泛癌分析后 FLAD1 和相关 microRNA 在乳腺癌中的显着诊断和预后价值

生物标志物的鉴定在癌症的诊断和预后中起着重要作用。在这项研究中，我们从在线数据库（Oncomine、cBioPortal、Breast Cancer Gene-Expression Miner、UALCAN、GEO、BCIP、TNMplot、ENCORI、Kaplan-Meier Plotter 、和链接组学）。我们发现FLAD1在多种不同类型的癌症中过度表达，尤其是在乳腺癌中，并且更高的FLAD1表达水平与 HER+、p53 突变体、淋巴结受累、NPI 3 期、基底样和三阴性相关组与其他乳腺癌亚组比较。FLAD1 _21-40 岁患者的表达水平高于其他年龄的患者，非洲裔美国人组的表达水平高于高加索人组。我们还分析了FLAD1相关的 microRNA 及其在乳腺癌中的预后价值。这项研究强调了FLAD1在癌症中的重要性，并为其作为癌症诊断和预后的生物标志物的潜力提供了证据。