Ceftizoxime (CFX) is used to reduce the infection caused by both gram-negative and gram-positive bacteria. In this report, a novel electrochemical sensor for CFX comprising a Cu(Him)₂ nanoparticles and ionic liquid (IL) hybride modified carbon paste electrode (CPE) has been developed. The structural properties of Cu(Him)₂ nanoparticles was characterized using energy-dispersive X-ray spectroscopy (EDX) analyses, X-ray diffraction (XRD), and field emission scanning electron microscopy (FESEM). The results illustrate that Cu(Him)₂/ILCPE exhibits an excellent electrocatalytic effect in the electrooxidation of CFX that leads to a considerable improvement in the corresponding anodic peak current. Under the best experimental conditions, the sensor exhibited a linear response to CFX from 2.0 to 1000.0 μM, with a limit of detection (LOD) of 0.5 nM. Finally, this also allows the development of a highly sensitive voltammetric sensor for the determination of CFX in pharmaceutical and biological samples.

头孢唑肟 (CFX) 用于减少由革兰氏阴性菌和革兰氏阳性菌引起的感染。在本报告中，开发了一种用于 CFX 的新型电化学传感器，该传感器包含 Cu(Him) ₂纳米颗粒和离子液体 (IL) 混合改性碳糊电极 (CPE)。使用能量色散 X 射线光谱 (EDX) 分析、X 射线衍射 (XRD) 和场发射扫描电子显微镜 (FESEM) 表征Cu(Him) ₂纳米粒子的结构特性。结果表明，Cu(Him) ₂/ILCPE 在 CFX 的电氧化中表现出优异的电催化效果，导致相应阳极峰值电流的显着改善。在最佳实验条件下，传感器对 CFX 的线性响应范围为 2.0 至 1000.0 μM，检测限 (LOD) 为 0.5 nM。最后，这也允许开发用于测定药物和生物样品中 CFX 的高灵敏度伏安传感器。