The aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), and Kolliphor® P188 (KP) for possible application in the design of nano-formulations. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM) revealed the physical characteristics of the various sample compositions without any apparent interaction. The Fourier transform infrared spectroscopy (FTIR)’s spectra of the physical mixtures showed their characteristic absorption bands with broadening and overlapping of bands in some instances, but no appearance of new bands was observed. The study revealed the physical form stability of the evaluated components after the storage period and lack of definite pharmaceutical incompatibility between them. Thus, the selected drugs and excipients could be used for the development of pharmaceutical nano-formulations.

中文翻译：

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使用二元、三元和多组合方法研究三氯生和氟比洛芬与药物制剂赋形剂的物理化学相容性

该研究的目的是评估三氯生 (TCS) 和氟比洛芬 (FLB) 与聚ε-己内酯 (PCL)、壳聚糖 (CS) 和 Kolliphor® P188 (KP) 的适用性，以便在纳米设计中的可能应用。 - 配方。差示扫描量热法 (DSC)、X 射线粉末衍射 (XRPD) 和扫描电子显微镜 (SEM) 揭示了各种样品组合物的物理特性，没有任何明显的相互作用。物理混合物的傅里叶变换红外光谱 (FTIR) 的光谱显示出它们的特征吸收带，在某些情况下带加宽和重叠，但没有观察到新带的出现。该研究揭示了评估成分在储存期后的物理形态稳定性以及它们之间缺乏明确的药物不相容性。因此，