Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history. Novel large-scale genomic and metabolomics approaches are now helping stratify their physiopathology. In this review, we show how various genetic alterations skew activation pathways and orient metabolic rewiring in sarcomas. We provide an update on the contribution of newly described mechanisms of metabolic regulation. We underscore mechanisms that are relevant to sarcomagenesis or shared with other cancers. We then discuss how diverse metabolic landscapes condition the tumor microenvironment, anti-sarcoma immune responses and prognosis. Finally, we review current attempts to control sarcoma growth using metabolite-targeting drugs.

中文翻译：

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肉瘤的代谢景观

代谢重组为癌症提供了新的治疗机会。直到最近，由于软组织肉瘤的组织起源、组织学定义和潜在的遗传史不同，有关软组织肉瘤的信息还很少。新颖的大规模基因组学和代谢组学方法现在正在帮助对其病理生理学进行分层。在这篇综述中，我们展示了各种遗传改变如何扭曲激活途径并定向肉瘤中的代谢重新布线。我们提供了新描述的代谢调节机制的贡献的最新信息。我们强调与肉瘤发生相关或与其他癌症共有的机制。然后我们讨论不同的代谢景观如何影响肿瘤微环境、抗肉瘤免疫反应和预后。最后，我们回顾了当前使用代谢物靶向药物控制肉瘤生长的尝试。