For almost 20 years, late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been the reference standard for the non-invasive assessment of myocardial viability. Since the blood pool often appears equally bright as the enhanced scar regions, detection of subendocardial scar patterns can be challenging. Various novel LGE methods have been proposed that null or suppress the blood signal by employing additional magnetization preparation mechanisms. This review aims to provide a comprehensive overview of these dark-blood LGE methods, discussing the magnetization preparation schemes and findings in phantom, preclinical, and clinical studies. Finally, conclusions on the current evidence and limitations are drawn and new avenues for future research are discussed. Dark-blood LGE methods are a promising new tool for non-invasive assessment of myocardial viability. For a mainstream adoption of dark-blood LGE, however, clinical availability and ease of use are crucial.

中文翻译：

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暗血晚期钆增强心血管磁共振改善心内膜下疤痕的检测：现有技术的回顾


近 20 年来，晚期钆增强 (LGE) 心血管磁共振 (CMR) 一直是无创评估心肌活力的参考标准。由于血池通常看起来与增强的疤痕区域同样明亮，因此检测心内膜下疤痕模式可能具有挑战性。已经提出了各种新颖的 LGE 方法，通过采用额外的磁化准备机制来消除或抑制血液信号。本综述旨在对这些暗血 LGE 方法进行全面概述，讨论磁化制备方案以及体模、临床前和临床研究中的发现。最后，对当前证据和局限性得出结论，并讨论未来研究的新途径。暗血 LGE 方法是一种有前途的非侵入性评估心肌活力的新工具。然而，对于暗血 LGE 的主流采用，临床可用性和易用性至关重要。