Abstract

Ornithogalum caudatum Ait (OCA) is a natural product used in Chinese traditional medicine. The cholestane saponin OSW-1 is isolated from plant OCA and has recently been shown to have potent cytotoxic effects against different types of cancers. The therapeutic efficacy of OSW-1 on prostate cancer and its underlying mechanism are yet to be established. OSW-1 inhibited the growth of prostate cancer cells by interrupting the interaction between mTOR and Rictor/mTORC2. This mechanism showed a better therapeutic outcome than that of the conventional inhibition of mTOR and provided a basis for as sisting modern prostate cancer treatment strategies.

摘要

Ornithogalum caudatum Ait (OCA) 是一种用于中药的天然产物。胆甾烷皂苷 OSW-1 是从植物 OCA 中分离出来的，最近已显示对不同类型的癌症具有有效的细胞毒性作用。OSW-1对前列腺癌的治疗效果及其潜在机制尚待确定。OSW-1 通过中断 mTOR 和 Rictor/mTORC2 之间的相互作用来抑制前列腺癌细胞的生长。这种机制显示出比常规抑制 mTOR 更好的治疗结果，并为作为现代前列腺癌治疗策略的辅助提供了基础。