3-Acylquinolines possess widespread applications in functional chemicals. However, the convenient and selective synthesis of such important substructures has to date remained a challenge. Herein, we report a method to access 3-acylquinolines from α, β-unsaturated ketones and 2-aminoaryl alcohols in one pot with a copper nanocatalyst supported on nitrogen-silica-doped carbon (Cu/N−SiO₂−C). Mechanistically, the construction of the product involves a cascade procedure including radical-type oxidation of 2-aminoaryl alcohols, aza-Michael addition and annulation. This developed protocol proceeds with merits of mild reaction conditions, good functional group tolerance, earth-abundant and reusable copper catalyst, easily available stocks and O₂ as the sole oxidant, which provides an alternative way for the sustainable synthesis of quinoline derivatives.

中文翻译：

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α, β-不饱和酮和 2-氨基芳醇的级联反应用于铜纳米催化剂合成 3-酰基喹啉

3-酰基喹啉在功能化学品中有着广泛的应用。然而，迄今为止，这种重要子结构的方便和选择性合成仍然是一个挑战。在此，我们报告了一种在一个锅中使用负载在氮-二氧化硅掺杂碳 (Cu/N-SiO ₂ -C)上的铜纳米催化剂从 α, β-不饱和酮和 2-氨基芳基醇中获得 3-酰基喹啉的方法。从机制上讲，该产品的构建涉及级联程序，包括 2-氨基芳醇的自由基型氧化、氮杂-迈克尔加成和环化。该开发的方案具有反应条件温和、官能团耐受性好、铜催化剂丰富且可重复使用、易于获得的库存和 O _{2 等}优点。 作为唯一的氧化剂，为喹啉衍生物的可持续合成提供了另一种途径。