C−N bond formation reactions have garnered a lot of interest in recent years due to the predominance of nitrogen-containing compounds in most pharmacological medications. Since traditional approaches have several limitations, the transition metal-catalyzed C−H amidation/amination process has arisen as a more atom-friendly option. Because there are so many distinct kinds of C−H bonds in organic molecules, selective amidation of C−H bonds has always been a challenge. In this scenario, the directing-group-assisted C−H amidation has received considerable attention, especially with inexpensive metal cobalt, due to its unique properties and efficiency. We summarize recent developments in cobalt-catalyzed directing-group-aided C−H bond amidation reactions in this review. We briefly discuss the evolution of directing group preferences and their function in the site selection.

中文翻译：

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钴催化、导向基团辅助的 C−H 键酰胺化反应的最新进展

近年来，由于含氮化合物在大多数药理药物中占主导地位，CN 键形成反应引起了人们的广泛关注。由于传统方法有几个局限性，过渡金属催化的 C-H 酰胺化/胺化过程已成为一种对原子更友好的选择。由于有机分子中有许多不同种类的 CH 键，因此 CH 键的选择性酰胺化一直是一个挑战。在这种情况下，定向基团辅助的 C-H 酰胺化因其独特的性质和效率而受到了相当多的关注，尤其是对于廉价的金属钴。我们在这篇综述中总结了钴催化的导向基团辅助的 C-H 键酰胺化反应的最新进展。