Objective

To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU).

Methods

Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m², who were free of knee OA at baseline. Demographics were collected by questionnaires at baseline. All menisci at both baseline and FU were automatically segmented from MRI scans to obtain the meniscus volume and the change over time (delta volume). Baseline and FU meniscus body extrusion was quantitatively measured on mid-coronal proton density MR images. A structural equation model was created to assess the interplay between both medial meniscus volume and central extrusion at baseline, delta volume, delta extrusion, and incident radiographic knee OA at FU.

Results

The structural equation modeling yielded a fair to good fit of the data. The direct effects of both medial meniscus volume and extrusion at baseline on incident OA were statistically significant (Estimate = 0.124, p = 0.029, and Estimate = 0.194, p < 0.001, respectively). Additional indirect effects on incident radiographic OA through delta meniscus volume or delta meniscus extrusion were not statistically significant.

Conclusion

Baseline medial meniscus volume and extrusion were associated to incidence of radiographic knee OA at FU in middle-aged overweight and obese women, while their changes were not involved in these effects. To prevent knee OA, interventions might need to target the onset of meniscal pathologies rather than their progression.

中文翻译：

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半月板体积和挤压的变化与膝关节骨性关节炎的发展有关吗？结构方程模型

客观的

在 30 个月的随访 (FU) 中探索内侧半月板体积（变化）、半月板挤压和影像学膝关节骨关节炎 (OA) 发展之间的相互作用。

方法

使用了来自超重女性膝骨关节炎预防研究的数据。^{该队列包括 407 名体重指数≥27 kg/m 2}的中年女性，她们在基线时没有膝关节骨关节炎。在基线时通过问卷收集人口统计数据。基线和 FU 的所有半月板都从 MRI 扫描中自动分割，以获得半月板体积和随时间的变化（增量体积）。在冠状中部质子密度 MR 图像上定量测量基线和 FU 半月板体挤压。创建了一个结构方程模型来评估内侧半月板体积和基线中央挤压、δ 体积、δ 挤压和 FU 处的入射 X 线膝关节 OA 之间的相互作用。

结果

结构方程建模产生了一个公平到良好的数据拟合。内侧半月板体积和基线挤压对事件 OA 的直接影响具有统计学意义（分别估计 = 0.124、p  = 0.029 和估计 = 0.194、p  < 0.001）。通过 delta 半月板体积或 delta 半月板挤压对事件放射影像 OA 的其他间接影响没有统计学意义。

结论

基线内侧半月板体积和挤压与中年超重和肥胖女性 FU 时 X 线膝关节 OA 的发生率相关，而它们的变化与这些影响无关。为了预防膝关节骨关节炎，干预措施可能需要针对半月板病变的发作而不是其进展。