The neuropathological changes of limbic-predominant age-related TDP-43 encephalopathy (LATE) are frequent in the aged population and are now recognized as a cause of memory impairment. However, it remains unknown if this proteinopathy is also present in other primate species. We thus investigated the presence and distribution of TDP-43 pathology in the hippocampus and amygdala of 7 aged memory-impaired rhesus macaques (Macaca mulatta, 18–32 years old) from 2 different cohorts. While present in an FTLD-TDP case used as a positive control for immunostaining, we found no TDP-43 or phosphorylated TDP-43 immunoreactive neuronal cytoplasmic inclusion in the amygdala or the hippocampus of these aged animals (as well as in young and mature macaques used as negative controls). We concluded that LATE is probably a human-specific condition, such as many other proteinopathies, and does not participate in age-related memory impairment in non–human primates.

边缘主导的年龄相关性 TDP-43 脑病 (LATE) 的神经病理学变化在老年人群中很常见，现在被认为是记忆障碍的一个原因。然而，尚不清楚这种蛋白质病是否也存在于其他灵长类动物中。因此，我们研究了 7 只老年记忆受损恒河猴 ( Macaca mulatta,18-32 岁）来自 2 个不同的群组。虽然存在于用作免疫染色阳性对照的 FTLD-TDP 病例中，但我们在这些老年动物（以及年轻和成熟的猕猴）的杏仁核或海马体中没有发现 TDP-43 或磷酸化的 TDP-43 免疫反应性神经元细胞质包涵体用作阴性对照）。我们得出结论，LATE 可能是人类特有的疾病，例如许多其他蛋白质病，并且不参与非人类灵长类动物与年龄相关的记忆障碍。