Poly(2-hydroxyethyl methacrylate) hydrogels doped with copper nanoparticles,Journal of Nanoparticle Research

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Poly(2-hydroxyethyl methacrylate) hydrogels doped with copper nanoparticles
Journal of Nanoparticle Research ( IF 2.1 ) Pub Date : 2021-07-21 , DOI: 10.1007/s11051-021-05281-7
Praveen ₁ , Stephen A. Moggach ₁ , Martin Saunders _{1,

2} , Matthew Myers _{1,

3} , Traian V. Chirila _{1,

4,

5,

6,

7} , Murray V. Baker _{1,

4} , Shuko Suzuki ₄ , Christine F. Carson ₈ , Peta L. Clode _{2,

9}

Affiliation

UWA School of Molecular Sciences, The University of Western Australia, Crawley, WA, 6009, Australia
Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, Crawley, WA, 6009, Australia
Commonwealth Scientific and Industrial Research Organisation, Energy, 26 Dick Perry Avenue, Kensington, WA, 6155, Australia
Queensland Eye Institute, 140 Melbourne Street, South Brisbane, Queensland, 4101, Australia
Faculty of Science and Engineering, Queensland University of Technology, Brisbane, Queensland, 4001, Australia
Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, Queensland, 4072, Australia
Faculty of Medicine, The University of Queensland, Herston, Queensland, 4029, Australia
UWA School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia
UWA School of Biological Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia

Poly(2-hydroxyethyl methacrylate) hydrogels incorporating copper nanoparticles (Cu-PHEMA) were prepared by a two-step process. In the first step, porous PHEMA hydrogels containing aqueous Cu(II) were formed by photo-induced phase separation polymerization in aqueous formulations containing 2-hydroxyethyl methacrylate (HEMA), a photoinitator, a cross-linker, and CuSO₄. In the second step, the Cu(II) ions were reduced to Cu(0) (Cu NPs) by hydrazine. The Cu-PHEMA hydrogels were red-brown due to the presence of the Cu NPs, and X-ray diffraction studies confirmed the NPs were crystalline Cu and not CuO. The porous PHEMA and Cu-PHEMA hydrogels exhibited the polymer droplet morphology characteristic of sponges formed by induced phase separation polymerization of HEMA in water. The Cu NPs were stable inside the hydrogel, and leaching of Cu NPs into water was very slow. Leached Cu NPs moderately inhibited the growth of Escherichia coli or Staphylococcus aureus bacteria in the surrounding medium. Incorporation of Cu NPs inside PHEMA hydrogels did not change compression strength of hydrogels.

Graphical abstract

中文翻译：

掺杂有铜纳米颗粒的聚（2-羟乙基甲基丙烯酸酯）水凝胶

通过两步法制备了包含铜纳米粒子 (Cu-PHEMA) 的聚（2-羟乙基甲基丙烯酸酯）水凝胶。第一步，在含有 2-羟乙基甲基丙烯酸酯 (HEMA)、光引发剂、交联剂和 CuSO _{4 的}水性配方中，通过光诱导相分离聚合形成含有水性 Cu(II) 的多孔 PHEMA 水凝胶. 在第二步中，Cu(II) 离子被肼还原为 Cu(0) (Cu NPs)。由于 Cu NPs 的存在，Cu-PHEMA 水凝胶呈红褐色，X 射线衍射研究证实 NPs 是结晶 Cu 而不是 CuO。多孔 PHEMA 和 Cu-PHEMA 水凝胶表现出由 HEMA 在水中诱导相分离聚合形成的海绵的聚合物液滴形态特征。Cu NPs 在水凝胶内是稳定的，Cu NPs 浸入水中非常缓慢。浸出的Cu NPs适度抑制周围培养基中大肠杆菌或金黄色葡萄球菌的生长。在 PHEMA 水凝胶中加入 Cu NPs 不会改变水凝胶的压缩强度。

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更新日期：2021-07-22

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