An efficient synthesis of 2-(4-(benzyloxy)phenyl)-N, N-dimethylacetamide substantially free from impurities – Synthesis & characterization of novel impurities,Results in Chemistry

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An efficient synthesis of 2-(4-(benzyloxy)phenyl)-N, N-dimethylacetamide substantially free from impurities – Synthesis & characterization of novel impurities
Results in Chemistry ( IF 2.5 ) Pub Date : 2021-07-21 , DOI: 10.1016/j.rechem.2021.100160
Sachin Sonavane ₁ , Sachin Mokal ₁ , Shubham Wadekar ₁ , Satish Wakchaure ₁ , Sharayu Deshmukh ₁

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An improved process developed for the 2-(4-(Benzyloxy)phenyl)-N, N-dimethylacetamide (BPA) which is key starting material for the synthesis of drug O-desmethylvenlafaxine succinate and asperphenamate was described to eliminate the impurities which will be formed during the process. The best reaction conditions were identified by evaluating the impurity profile and their formation during the synthesis. The optimization of the process was made to control the impurities which was one of the critical parameters in the synthesis of BPA. Both the novel impurities formed during the synthesis were identified, synthesized and characterized.

中文翻译：

一种基本不含杂质的 2-(4-(苄氧基)苯基)-N, N-二甲基乙酰胺的有效合成——新型杂质的合成和表征

描述了一种为 2-(4-(苄氧基)苯基)-N, N-二甲基乙酰胺 (BPA) 开发的改进工艺，该工艺是合成药物 O-去甲基文拉法辛琥珀酸酯和阿斯芬那酯的关键原料，用于消除杂质过程中形成。通过评估合成过程中的杂质分布及其形成来确定最佳反应条件。对工艺进行优化以控制杂质，这是合成双酚A的关键参数之一。在合成过程中形成的两种新杂质都被鉴定、合成和表征。

更新日期：2021-07-27

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