Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome — known as the senescence-associated secretory phenotype — is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.

衰老细胞随着年龄的增长在所有组织中积累。尽管衰老细胞经历细胞周期停滞，但这些细胞仍保持代谢活跃，其分泌组（称为衰老相关分泌表型）负责全身性促炎状态，这有助于炎症微环境。衰老细胞可以在衰老的前列腺和衰老相关的分泌表型中找到，并且可能与 BPH 和前列腺癌有关。事实上，许多信号通路为衰老在 BPH 和前列腺癌中的作用提供了生物学上的合理性，尽管很难证明因果关系。衰老作为前列腺疾病机制的理论具有许多临床意义，并可能为未来的靶向治疗提供机会。